Biochemical basis for the essential genetic requirements of RecA and the beta-clamp in Pol V activation.

@article{Fujii2009BiochemicalBF,
  title={Biochemical basis for the essential genetic requirements of RecA and the beta-clamp in Pol V activation.},
  author={Shingo Fujii and Robert P Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 35},
  pages={14825-30}
}
In Escherichia coli, it is genetically well established that the beta-clamp and RecA are essential cofactors that endow DNA polymerase (Pol) V with lesion bypass activity. However, the biochemical basis for these requirements is still largely unknown. Because the process of translesion synthesis (TLS) requires that the specialized DNA polymerase synthesize in a single binding event a TLS patch that is long enough to resist external proofreading, it is critical to monitor Pol V burst synthesis… CONTINUE READING

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