Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.

@article{He2006BiochemicalBF,
  title={Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.},
  author={Martin He\ss and Marc L Mendillo and Dan J. Mazur and Richard D Kolodner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 3},
  pages={558-63}
}
Here, the ATP-binding, ATP hydrolysis, mispair-binding, sliding clamp formation, and Mlh1-Pms1 complex interaction properties of dominant mutant Msh2-Msh6 complexes have been characterized. The results demonstrate two mechanisms for dominance. In one, seen with the Msh6-S1036P and Msh6-G1067D mutant complexes, the mutant complex binds mispaired bases, is defective for ATP-induced sliding clamp formation and assembly of ternary complexes with Mlh1-Pms1, and occludes mispaired bases from other… CONTINUE READING

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