• Corpus ID: 2189717

Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin.

@article{Valenzuela1994BiochemicalBO,
  title={Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin.},
  author={Alfonso Valenzuela and A Garrido},
  journal={Biological research},
  year={1994},
  volume={27 2},
  pages={
          105-12
        }
}
The flavonoid silymarin and one its structural components, silibinin, have been well characterized as hepato-protective substances. However, little is known about the biochemical mechanisms of action of these substances. This review deals with recent investigations to elucidate the molecular action of the flavonoid. Three levels of action have been proposed for silymarin in experimental animals: a) as an antioxidant, by scavenging prooxidant free radicals and by increasing the intracellular… 

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