Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus.

@article{Yu2011BiochemicalAS,
  title={Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus.},
  author={Xuekui Yu and Sanket U Shah and Manfred Lee and Wei Dai and Pierrette Lo and William J Britt and Hua Zhu and Fenyong Liu and Z. Hong Zhou},
  journal={Journal of structural biology},
  year={2011},
  volume={174 3},
  pages={451-60}
}
Human cytomegalovirus (HCMV) is the most genetically and structurally complex human herpesvirus and is composed of an envelope, a tegument, and a dsDNA-containing capsid. HCMV tegument plays essential roles in HCMV infection and assembly. Using cryo electron tomography (cryoET), here we show that HCMV tegument compartment can be divided into two sub-compartments: an inner and an outer tegument. The inner tegument consists of densely-packed proteins surrounding the capsid. The outer tegument… CONTINUE READING

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