Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis.

@article{Gago2006BiochemicalAS,
  title={Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis.},
  author={Gabriela Gago and Daniel Kurth and Lautaro Diacovich and Shiou-Chuan Tsai and Hugo Gramajo},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 2},
  pages={477-86}
}
Pathogenic mycobacteria contain a variety of unique fatty acids that have methyl branches at an even-numbered position at the carboxyl end and a long n-aliphatic chain. One such group of acids, called mycocerosic acids, is found uniquely in the cell wall of pathogenic mycobacteria, and their biosynthesis is essential for growth and pathogenesis. Therefore, the biosynthetic pathway of the unique precursor of such lipids, methylmalonyl coenzyme A (CoA), represents an attractive target for… CONTINUE READING

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