Biochemical and structural analysis of the IgE binding sites on ara h1, an abundant and highly allergenic peanut protein.

@article{Shin1998BiochemicalAS,
  title={Biochemical and structural analysis of the IgE binding sites on ara h1, an abundant and highly allergenic peanut protein.},
  author={David S. Shin and Cesar M. Compadre and Soheila J. Maleki and Randall A. Kopper and H. Grant Sampson and Shan Ku Huang and Arvil Wesley Burks and G. A. Bannon},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 22},
  pages={13753-9}
}
Allergy to peanut is a significant IgE-mediated health problem because of the high prevalence, potential severity, and chronicity of the reaction. Ara h1, an abundant peanut protein, is recognized by serum IgE from >90% of peanut-sensitive individuals. It has been shown to belong to the vicilin family of seed storage proteins and to contain 23 linear IgE binding epitopes. In this communication, we have determined the critical amino acids within each of the IgE binding epitopes of Ara h1 that… CONTINUE READING

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