Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants.

  title={Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants.},
  author={Carmelo Bruno Bruni and Vittorio Colantuoni and Ludovico Sbordone and R. Cortese and Francesco Blasi},
  journal={Journal of bacteriology},
  volume={130 1},
Escherichia coli K-12 hisT mutants were isolated, and their properties were studied. These mutants are derepressed for the histidine operon, map close to the purF locus at about 49.5 min on the E. coli linkage map, and lack pseudouridylate synthetase activity. The defect in this enzyme leads to the absence of pseudouridines in the anticodon loop of several transfer ribonucleic acid species, as evidenced by the altered elution profile on reversed-phase chromatography and resistance to amino acid… CONTINUE READING

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