• DOI:10.1016/j.pharmthera.2019.107400
Corpus ID: 201041989

Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.

@article{Isoherranen2019BiochemicalAP,
  title={Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.},
  author={N. Isoherranen and Guo Zhong},
  journal={Pharmacology & therapeutics},
  year={2019},
  pages={
          107400
        }
}

N. Isoherranen, Guo Zhong

Published 2019

Biology, Medicine

Pharmacology & therapeutics

The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA) metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 family enzymes, CYP26A1, CYP26B1 and CYP26C1 have all been shown to metabolize all-trans-retinoic acid (atRA) as well as 9-cisRA and 13-cisRA isomers and primary metabolites 4-OH-RA and 4-oxo-RA with high efficiency. While no crystal structures of CYP26 enzymes are available, the binding of various ligands has been extensively explored… CONTINUE READING

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