Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.

  title={Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.},
  author={N. Isoherranen and Guo Zhong},
  journal={Pharmacology & therapeutics},
  • N. Isoherranen, Guo Zhong
  • Published 2019
  • Biology, Medicine
  • Pharmacology & therapeutics
  • The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA) metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 family enzymes, CYP26A1, CYP26B1 and CYP26C1 have all been shown to metabolize all-trans-retinoic acid (atRA) as well as 9-cisRA and 13-cisRA isomers and primary metabolites 4-OH-RA and 4-oxo-RA with high efficiency. While no crystal structures of CYP26 enzymes are available, the binding of various ligands has been extensively explored… CONTINUE READING
    18 Citations
    Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes
    • C. Roberts
    • Biology, Medicine
    • Journal of developmental biology
    • 2020
    • 2
    • PDF
    Analysis of vitamin A and retinoids in biological matrices.
    Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice
    • J. Snyder, Guo Zhong, +8 authors N. Isoherranen
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2020
    Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier.
    • 1
    Absence of CD36 alters systemic vitamin A homeostasis
    • PDF
    New luciferin-based probe substrates for human CYP26A1


    Cytochrome P450s in the regulation of cellular retinoic acid metabolism.
    • 194
    Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes*
    • 26
    • PDF