Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

@article{Drake1989BiochemicalAP,
  title={Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.},
  author={Fred Drake and Glenn A. Hofmann and H F Bartus and Michael Mattern and Stanley T. Crooke and Christopher K. Mirabelli},
  journal={Biochemistry},
  year={1989},
  volume={28 20},
  pages={8154-60}
}
The p170 and p180 forms of topoisomerase II have been compared. The concentration dependence of ATP for catalytic activity of the two forms of the enzyme was identical, and each was equally sensitive to novobiocin. Orthovanadate was found to be a potent inhibitor of catalytic activity of both p170 and p180, with an IC50 value of about 2 microM for each. Under standard reaction conditions, relaxation of supercoiled pBR322 by p180 was highly processive, while p170 performed the same reaction in a… CONTINUE READING

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