Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4-tetrahydroisoquinoline-induced parkinsonism in the mouse.

@article{Abe2001BiochemicalAP,
  title={Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4-tetrahydroisoquinoline-induced parkinsonism in the mouse.},
  author={Kazuho Abe and Kyoji Taguchi and T Wasai and Jim Y Ren and Iku Utsunomiya and Toshimichi Shinohara and Tadashi Miyatake and Takehiro Sano},
  journal={Brain research},
  year={2001},
  volume={907 1-2},
  pages={134-8}
}
We administered 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1-BnTIQ; 80 mg/kg, i.p.), an endogenous neurotoxin known to cause bradykinesia, the Parkinson's disease-like symptom, in order to obtain biochemical and pathological evidence of behavioral abnormalities. Immunohistochemical analysis demonstrated that 1-BnTIQ did not decrease the number of tyrosine hydroxylase-positive cells in the substantia nigra. Biochemical analysis demonstrated significantly increased striatal dopamine (DA) content… CONTINUE READING

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