Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules.

@article{Mankin1981BiochemicalAM,
  title={Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules.},
  author={Henry J. Mankin and Michael E. Johnson and L A Lippiello},
  journal={The Journal of bone and joint surgery. American volume},
  year={1981},
  volume={63 1},
  pages={131-9}
}
Since 1960, numerous studies have supported the thesis that the synthetic activity of articular chondrocytes is increased in osteoarthritis, but several recent reports have challenged this concept. To clarify this problem fully and also to define further the products of this increased synthesis, three experiments were performed in which the distribution and rates of synthesis of amino sugar-containing macromolecules in normal and osteoarthritic cartilage from the human femoral head were… CONTINUE READING
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