Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis

  title={Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis},
  author={Mohammad Hosein Farzaei and Seyedeh Farnaz Ghasemi-Niri and Amir Hossein Abdolghafari and Maryam Baeeri and Mahnaz Khanavi and Mona Navaei‐Nigjeh and M. Abdollahi and Roja Rahimi},
  journal={Pharmaceutical Biology},
  pages={429 - 436}
Abstract Context: Tragopogon graminifolius DC. (Compositae) (TG) has been proposed as an efficacious remedy for gastrointestinal ulcers in Iranian traditional medicine. Objective: The present study evaluates the efficacy of TG on experimental colitis and the responsible mechanisms. Materials and methods: After induction of IBD by 2,4,6-trinitrobenzenesulfonic acid (TNBS), rats received standardized ethanol extract of TG aerial part at 20, 30, or 50 mg/kg/d orally. After 12 d, the rats were… 
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