Corpus ID: 25473348

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

@article{Commins1987BiochemicalAH,
  title={Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.},
  author={D. L. Commins and G. Vosmer and R. M. Virus and W. Woolverton and C. Schuster and L. Seiden},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={241 1},
  pages={
          338-45
        }
}
  • D. L. Commins, G. Vosmer, +3 authors L. Seiden
  • Published 1987
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
    • (+/-)-3,4-Methylenedioxymethylamphetamine (MDMA) was administered s.c. to rats (10, 20 or 40 mg/kg b. wt.) and guinea pigs (20 mg/kg) twice a day for 4 days, 2 weeks before decapitation. Norepinephrine, dopamine and serotonin (5-HT) levels were assayed in the hippocampus, hypothalamus, striatum and neocortex. In rats, MDMA produced dose-dependent reductions in 5-HT in all brain regions examined. The highest dose also reduced norepinephrine and/or dopamine in some regions. The 20-mg/kg dose of… CONTINUE READING
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