Biochemical and histological alterations induced by fluid percussion brain injury in the rat.

@article{Toulmond1993BiochemicalAH,
  title={Biochemical and histological alterations induced by fluid percussion brain injury in the rat.},
  author={S Toulmond and Dani{\`e}le Duval and A. Serrano and Bernard Scatton and J{\'e}sus Benavides},
  journal={Brain research},
  year={1993},
  volume={620 1},
  pages={24-31}
}
In the present study we have characterized the time-course of the histopathological and biochemical alterations resulting from mechanical brain injury caused by lateral fluid percussion centered over the parietal cortex in the rat. The injury device used was an HPLC pump coupled to a solenoid valve which delivered a constant and short lasting (10 ms) impact pressure (1.6 atm). This traumatic procedure resulted in an accumulation of blood in the subarachnoid space and cortical edema at 4-24 h… CONTINUE READING