Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim.

@article{Song2000BiochemicalAG,
  title={Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim.},
  author={Zhiyin Song and Bin Guan and Aviv Bergman and Donald W. Nicholson and Nancy A. Thornberry and Erin P. Peterson and Hermann Steller},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 8},
  pages={2907-14}
}
In Drosophila melanogaster, the induction of apoptosis requires three closely linked genes, reaper (rpr), head involution defective (hid), and grim. The products of these genes induce apoptosis by activating a caspase pathway. Two very similar Drosophila caspases, DCP-1 and drICE, have been previously identified. We now show that DCP-1 has a substrate specificity that is remarkably similar to those of human caspase 3 and Caenorhabditis elegans CED-3, suggesting that DCP-1 is a death effector… CONTINUE READING

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