Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV.

@article{Ramos1998BiochemicalAG,
  title={Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV.},
  author={William Ramos and Guozhen Liu and Craig N. Giroux and Alan E. Tomkinson},
  journal={Nucleic acids research},
  year={1998},
  volume={26 24},
  pages={5676-83}
}
Here we demonstrate that the Saccharomyces cerevisiae DNA ligase activity, which we previously designated DNA ligase II, is encoded by the genomic DNA sequence YOR005c. Based on its homology with mammalian LIG4, this yeast gene has been named DNL4 and the enzyme activity renamed Dnl4. In agreement with others, we find that DNL4 is not required for… CONTINUE READING