Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

@article{Raabe1995BiochemicalAG,
  title={Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.},
  author={Thomas Raabe and Jean Paul Olivier and Barry Dickson and Xiangdong Liu and Gerald D. Gish and Tony J. Pawson and Ernst Hafen},
  journal={The EMBO journal},
  year={1995},
  volume={14 11},
  pages={2509-18}
}
The Drk SH3-SH2-SH3 adaptor protein has been genetically identified in a screen for rate-limiting components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in the developing eye of Drosophila. It provides a link between the activated Sev receptor and Sos, a guanine nucleotide release factor that activates Ras1. We have used a combined biochemical and genetic approach to study the interactions between Sev, Drk and Sos. We show that Tyr2546 in the cytoplasmic tail of Sev is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.

Biochemical and genetic analysis of the Drk SH 2 / SH 3 adaptor protein of Drosophila

  • Raabe, T Raabe, J P Olivier, B Dickson, G D Gish, E. Hafen
  • EMBO J .
  • 1995

Similar Papers

Loading similar papers…