Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1.

Abstract

AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. Its homolog in yeast, SNF1, is activated in response to glucose depletion and other stresses. The catalytic (alpha) subunit of AMPK/SNF1, Snf1 in yeast, contains a protein Ser/Thr kinase domain (KD), an auto-inhibitory domain (AID), and a region… (More)
DOI: 10.1016/j.bbrc.2010.05.083

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