Biochemical and functional properties of the store-operated Ca2+ channels.

  title={Biochemical and functional properties of the store-operated Ca2+ channels.},
  author={Gin{\'e}s M Salido and Stewart O. Sage and Juan Antonio Rosado},
  journal={Cellular signalling},
  volume={21 4},
Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) entry in excitable and non-excitable cells. The best-characterised store-operated current is I(CRAC), but other currents activated by Ca(2+) store depletion have also been reported. The recent identification of the proteins stromal interaction molecule 1 (STIM1) and Orai1 has shed new light on the nature and regulation of SOC channels. STIM1 has been presented as the endoplasmic reticulum (ER) Ca(2+) sensor that communicates… CONTINUE READING

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