Biochemical and functional evidence of supersensitive platelet alpha 2-adrenoceptors in major affective disorder. Effect of long-term lithium carbonate treatment.

@article{GarcaSevilla1986BiochemicalAF,
  title={Biochemical and functional evidence of supersensitive platelet alpha 2-adrenoceptors in major affective disorder. Effect of long-term lithium carbonate treatment.},
  author={Jes{\'u}s Andr{\'e}s Garc{\'i}a-Sevilla and Jos{\'e} Guim{\'o}n and P. Garc{\'i}a-Vallejo and Montserrat Fuster},
  journal={Archives of general psychiatry},
  year={1986},
  volume={43 1},
  pages={51-7}
}
The hypothesis that depressive illness is related to supersensitive alpha 2-adrenoceptors in the brain has been tested indirectly in blood platelets. The binding of tritiated clonidine hydrochloride to platelet membranes, a ligand that labels only the high-affinity state of the alpha 2-adrenoceptor that is coupled with cell functions, and the aggregation… CONTINUE READING