Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.

@article{Menrad1993BiochemicalAF,
  title={Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.},
  author={Andreas Menrad and Daniel Speicher and Jutta Wacker and Meenhard Herlyn},
  journal={Cancer research},
  year={1993},
  volume={53 6},
  pages={1450-5}
}
A cell surface protein expressed on melanoma cells, but not on normal melanocytes, was biochemically and functionally characterized. Microsequencing of the M(r) 143,000 affinity-purified protein revealed amino acid sequence identity to aminopeptidase N (EC 3.4.11.2). In situ expression, indirect immunofluorescence, and Western blotting demonstrated that aminopeptidase N is tightly associated with extracellular matrix components. A specific polyclonal antiserum and the competitive inhibitors of… CONTINUE READING

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