Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA‐1, Mo‐1 and p!50,95

@article{Keizer1985BiochemicalAF,
  title={Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA‐1, Mo‐1 and p!50,95},
  author={G. D. Keizer and Jannie Borst and Carl G. Figdor and Hergen Spits and Frank Miedema and Cox Terhorst and Jan E. de Vries},
  journal={European Journal of Immunology},
  year={1985},
  volume={15}
}
The human leukocyte function‐associated (LFA‐1) antigen, the monocyte differentiation antigen Mo‐1 which is characterized as the C3bi receptor and the glycoprotein p150,95 are characterized biochemically. Immunoprecipitations carried out with 6 different monoclonal antibodies (mAb) against LFA‐1 indicated that four mAb (SPV‐ L1, SPV‐L5, SPV‐L7 and SPV‐L11) were directed against the a chain, whereas mAb CLB54 and MHM‐23 were found to react with the common β chain of LFA‐1, Mo‐1 and p150,95. LFA… 
Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes
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Co‐expression of Mac‐1 and p150,95 on CD5+ B cells. Structural and functional characterization in a human chronic lymphocytic leukemia
The leukocyte adhesion receptors (LAR) Mac‐1 and p150,95 were thought to occur only on myeloid cells, but recently, mouse Ly‐1+ (CD5+) B and pro‐B cells were shown to bind M1/70 monoclonal antibody,
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Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human monocytes to melanoma and endothelial cells.
TLDR
The results indicate that not only LFA-1 but also CR3 and p150,95 can mediate adhesion to target cells in suspension, but that monocyteAdhesion to monolayers is caused by a different mechanism in which the p 150,95 molecule seems to play a prominent role.
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References

SHOWING 1-10 OF 22 REFERENCES
Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis
TLDR
The lack of maturation of alpha'L to alpha L and the deficiency of the alpha subunits at the cell surface and in latent pools suggests that association with the beta subunit is required for alpha subunit processing and transport to the cellsurface or to latent pools.
Both Fc receptors and lymphocyte‐function‐associated antigen 1 on human Tγ lymphocytes are required for antibody‐dependent cellular cytotoxicity (killer cell activity)
TLDR
It was shown that L FA‐1 and the Fc receptor on Tγ cells did not comodulate and it was concluded that Fc receptors and LFA‐1 are independent membrane structures, both required for the killer cell activity of Tγ Cells.
The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.
TLDR
Three cell surface antigens associated with the cy tolytic T lymphocyte(CTL)-target cell interaction were identified by generation of monoclonal antibodies (MAb) against OKT4+, HLA-DR-specific CTL and selection for inhibition of cytolysis in a 51Cr-release assay to demonstrate the complexity of CTL-mediated cytotoxicity at the molecular level.
A human leukocyte differentiation antigen family with distinct alpha- subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule
TLDR
LFA-1, OKM1, and p150,95 constitute a novel family of functionally important human leukocyte antigens that share a common beta-subunit.
The T3 complex on human thymus‐derived lymphocytes contains two different subunits of 20 kDa
TLDR
Evidence is presented that the main 20‐kDa T3 antigen is comprised of, in fact, two structurally different molecules, one of these is a glycoprotein with a protein backbone of 14 kDa, the other is an unglycosylated protein of 20 kDa.
LFA‐1 and Lyt‐2,3, Molecules Associated with T Lymphocyte‐Mediated Killing; and Mac‐1, an LFA‐1 Homologue Associated with Complement Receptor Function 1
TLDR
Cytolytic activity displays all the hallmarks of specific immunity, i.e. it is highly specific for antigens on the eliciting cells, and it shows accelerated development and reaches.
Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence.
TLDR
Investigations of polymorphonuclear leukocyte (PMN) function were performed in a 5-yr-old white female with delayed umbilical cord separation, impaired pus formation, and a severe defect of PMN chemotaxis, providing new evidence that critical PMN surface glycoproteins are required to facilitate multiple adhesion-dependent cellular functions of the inflammatory response.
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor
TLDR
The results show that Mac-1 is either identical to CR3 or closely associated with CR3 function, one of the first cases in which a monoclonal antibody-defined differentiation antigen has been associated with a specific cell surface function.
Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines.
TLDR
The results presented here indicate that the antigens recognized by SPV-L1 and SPv-L5 are involved in various cytotoxic reactions.
Structural analysis of differentiation antigens Mo1 and Mo2 on human monocytes.
TLDR
Immunoprecipitation of Mo1- and Mo2-bearing structures from lysates of internally labeled cells indicates that these proteins are synthesized by human monocytes.
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