Corpus ID: 32955379

Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain.

  title={Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain.},
  author={B. Crute and A. F. Lewis and Z. Wu and J. Bushweller and N. Speck},
  journal={The Journal of biological chemistry},
  volume={271 42},
  • B. Crute, A. F. Lewis, +2 authors N. Speck
  • Published 1996
  • Medicine
  • The Journal of biological chemistry
  • The Runt domain is the DNA-binding domain defining a small family of transcription factors that are involved in important developmental processes. Developmental pathways controlled by Runt domain proteins include sex determination, neurogenesis, segmentation, and eye development in Drosophila and hematopoiesis in mammals. In addition to binding DNA, the Runt domain also mediates heterodimerization with another subunit called the core-binding factor beta (CBFbeta) subunit. In this study we… CONTINUE READING
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