Biochemical and biophysical characterization of a chimeric TRIM21-TRIM5alpha protein.

Abstract

The tripartite motif (TRIM) protein, TRIM5alpha, is an endogenous factor in primates that recognizes the capsids of certain retroviruses after virus entry into the host cell. TRIM5alpha promotes premature uncoating of the capsid, thus blocking virus infection. Low levels of expression and tendencies to aggregate have hindered the biochemical, biophysical… (More)
DOI: 10.1128/JVI.01559-08

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