Biochemical and behavioural effects of isamoltane, a β-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain

  title={Biochemical and behavioural effects of isamoltane, a $\beta$-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain},
  author={Lucy R{\'e}nyi and Lars-Gunnar Larsson and Stefan von Berg and B. E. Svensson and Gun Thorell and Svante B. Ross},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
SummaryThe biochemical and behavioural effects of isamoltane, a \-adrenoceptor and 5-HT1B receptor antagonist that has higher affinity for 5-HT1B receptors than for 5-HTIA receptors, on 5-HT neurotransmission in the rat brain were examined. In binding experiments isamoltane was found to be about five times more potent as a ligand for the 5-HT1B receptor than for the 5-HT1A receptor (Ki values 21 and 112 nmol/l, respectively). Isamoltane increased the K+-evoked overflow of 3H from 3H-5-HT loaded… 

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