Biochemical and behaviour changes induced by acute stress in a chronic variate stress model of depression: the effect of amitriptyline.

@article{Ferretti1995BiochemicalAB,
  title={Biochemical and behaviour changes induced by acute stress in a chronic variate stress model of depression: the effect of amitriptyline.},
  author={Carlo Ferretti and M. Blengio and Silvana Ricci Gamalero and Piera Ghi},
  journal={European journal of pharmacology},
  year={1995},
  volume={280 1},
  pages={19-26}
}
This paper examines the biochemical and behaviour changes induced by an acute stress (five 10-s, 1-mA foot-shocks) in three groups of rats: (1) never stressed, (2) subjected to chronic variate stress for 20 days, (3) subjected to the same chronic stress and treated with 5 mg/kg per day amitriptyline. After 15 min, acute stress led to a marked reduction in cortical beta-adrenoceptor and 5-HT2 receptor density, whereas the density of the 5-HT1A receptors was unchanged. Chronic stress also… CONTINUE READING

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