Biochemical and behavioral studies of the 5‐HT1B receptor agonist, CP‐94,253

@article{Koe1992BiochemicalAB,
  title={Biochemical and behavioral studies of the 5‐HT1B receptor agonist, CP‐94,253},
  author={Billie Kenneth Koe and Jann A. Nielsen and John Eugene Macor and James Heym},
  journal={Drug Development Research},
  year={1992},
  volume={26}
}
CP‐94,253, 3‐(1,2,5,6‐tetrahydro‐4‐pyridyl)‐5‐propoxypyrrolo[3,2‐b]pyridine, a new serotonergic ligand, was found to exhibit significantly greater binding affinity at 5‐HT1B receptors than at 5‐HT1A or 5‐HT1C receptors. Saturation studies showed CP‐94,253 to be a competitive inhibitor of [125l]iodocyanopindolol binding to 5‐HT1B sites. Its competition curve with this radioligand was shifted to the right (decreased affinity) in the presence of Gpp(NH)p, indicating an agonist function for CP‐94… 

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TLDR
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TLDR
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