Biochemical and Functional Evidence of p53 Homology Is Inconsistent with Molecular Phylogenetics for Distant Sequences

@article{Fernandes2008BiochemicalAF,
  title={Biochemical and Functional Evidence of p53 Homology Is Inconsistent with Molecular Phylogenetics for Distant Sequences},
  author={Andrew D. Fernandes and William R. Atchley},
  journal={Journal of Molecular Evolution},
  year={2008},
  volume={67},
  pages={51-67}
}
The tumor suppressor p53 is mutated in ∼50% of all human cancer cases worldwide. It is commonly assumed that the phylogenetic history of this important tumor suppressor has been thoroughly studied; however, few detailed studies of the entire extended p53 protein family have been reported, and none comprehensively and simultaneously consider functional, molecular, and phylogenetic data. Herein we examine a diverse collection of reported p53-like protein sequences, including representatives from… 
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  • 2009
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An important function of the p53 pathway in reproduction provides a plausible explanation for the evolution of p53 as a tumor suppressor gene and the positive selection of some alleles in the p 53 gene and its pathway.
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.
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The structural evolution of the p53 pathway is traced, from germ-line surveillance in simple multicellular organisms to its pluripotential role in humans, and some of these compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, personalized anticancer medicines.
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References

SHOWING 1-10 OF 82 REFERENCES
p63: Molecular complexity in development and cancer.
TLDR
Although the most ancient member of the p53 family, p63 is the most recently discovered and the least is known about this family member, and over-expression of select p63 splice variants is observed in many squamous carcinomas suggesting that p63 may act as an oncogene.
Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features
TLDR
The results indicate that targeting highly conserved regions for mutational and functional analysis may be efficient strategies for the study of cancer-related genes.
Identification and phylogenetic comparison of p53 in two distinct mussel species (Mytilus).
Ehp53, an Entamoeba histolytica protein, ancestor of the mammalian tumour suppressor p53.
TLDR
Ehp53 is believed to be the first p53-like protein found in protozoa and may be the evolutionary ancestor of the mammalian p53.
Structural aspects of the p53 protein in relation to gene evolution: a second look.
TLDR
The purpose of this review is to present the most recent data concerning the various structural features of the p53 protein with special emphasis on its flexibility, which plays a key role in regulation of its biological activity.
Ehp 53 , an Entamoeba histolytica protein , ancestor of the mammalian tumour suppressor p 53
TLDR
The identification of Ehp53, a p53-like Entamoeba histolytica protein, which binds to the human p53 DNA consensus sequence (oli-p53), is reported.
Identification and characterization of a p53 homologue in Drosophila melanogaster.
  • S. Jin, S. Martinek, A. Levine
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
It appears that p53 is structurally and functionally conserved from flies to mammals, and Drosophila will provide a useful genetic system to the further study of the p53 network.
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