Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update

  title={Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update},
  author={R. Vanholder and A. Pletinck and E. Schepers and G. Glorieux},
  • R. Vanholder, A. Pletinck, +1 author G. Glorieux
  • Published 2018
  • Biology, Medicine
  • Toxins
  • In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were… CONTINUE READING

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    Review on uremic toxins: classification, concentration, and interindividual variability.
    • 1,118
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    Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • 2,660
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    Advanced oxidation protein products as a novel marker of oxidative stress in uremia.
    • 1,427
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    Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.
    • 1,248
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    Normal and pathologic concentrations of uremic toxins.
    • 452
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    Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.
    • 646
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