Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update

@article{Vanholder2018BiochemicalAC,
  title={Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update},
  author={R. Vanholder and A. Pletinck and E. Schepers and G. Glorieux},
  journal={Toxins},
  year={2018},
  volume={10}
}
  • R. Vanholder, A. Pletinck, +1 author G. Glorieux
  • Published 2018
  • Biology, Medicine
  • Toxins
  • In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were… CONTINUE READING

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