Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update

@inproceedings{Vanholder2018BiochemicalAC,
  title={Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update},
  author={Raymond Camille Vanholder and Anneleen Pletinck and Eva Schepers and Griet Glorieux},
  booktitle={Toxins},
  year={2018}
}
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were… CONTINUE READING
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