Biochemical and Clinical Aspects of Methotrexate Neurotoxicity

@article{Vezmar2003BiochemicalAC,
  title={Biochemical and Clinical Aspects of Methotrexate Neurotoxicity},
  author={Sandra Vezmar and Achim Becker and Udo Bode and Ulrich Jaehde},
  journal={Chemotherapy},
  year={2003},
  volume={49},
  pages={104 - 92}
}
  • Sandra Vezmar, Achim Becker, +1 author Ulrich Jaehde
  • Published in Chemotherapy 2003
  • Medicine, Biology
  • Acute, subacute and chronic neurotoxicity have been observed after the administration of high-dose and/or intrathecal methotrexate (MTX). Acute toxicity is usually transient without permanent damage. Subacute and chronic toxicity are associated with changes in the brain and/or the spinal cord which may be progressive and even lead to coma and death in severe cases. It is believed that MTX can induce direct toxic effects to the CNS by damaging the neuronal tissue. Moreover, MTX interferes with… CONTINUE READING

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