Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

Abstract

RecQ helicases play an important role in preserving genomic integrity, and their cellular roles in DNA repair, recombination, and replication have been of considerable interest. Of the five human RecQ helicases identified, three are associated with genetic disorders characterized by an elevated incidence of cancer or premature aging: Werner syndrome, Bloom… (More)

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