Biochemical alterations in paromomycin-treated Leishmania donovani promastigotes

@article{Maarouf1997BiochemicalAI,
  title={Biochemical alterations in paromomycin-treated Leishmania donovani promastigotes},
  author={Mohammad Maarouf and Françoise Lawrence and Spencer Brown and Malka Robert-Gero},
  journal={Parasitology Research},
  year={1997},
  volume={83},
  pages={198-202}
}
Paromomycin is used for the treatment of leishmaniasis in humans, but little is known about its mechanism of action. Investigating the effect of this antibiotic on promastigotes of Leishmania donovani, we showed that inhibition of the multiplication of these parasites could be related to its effect on RNA synthesis and to modifications of membranous polar lipids and membrane fluidity, leading to altered membrane permeability. 
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