Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

@inproceedings{Kanow2017BiochemicalAO,
  title={Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye},
  author={Mark A Kanow and Michelle M Giarmarco and Connor S R Jankowski and Kristine Tsantilas and Abbi L. Engel and Jianhai Du and Jonathan D Linton and Christopher C. Farnsworth and Stephanie R Sloat and Austin M. Rountree and Ian Sweet and Ken J Lindsay and Edward D. Parker and Susan E Brockerhoff and Martin Sad{\'i}lek and Jennifer R Chao and James B Hurley},
  booktitle={eLife},
  year={2017}
}
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as… CONTINUE READING
6 Citations
70 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 70 references

On the metabolism of carcinoma cells

  • O Warburg, K. Posener, E. Negrelein
  • Bioschemische Zeitschrift
  • 2017
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…