Corpus ID: 39090599

Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.

@article{Holloszy1967BiochemicalAI,
  title={Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.},
  author={J. Holloszy},
  journal={The Journal of biological chemistry},
  year={1967},
  volume={242 9},
  pages={
          2278-82
        }
}
  • J. Holloszy
  • Published 1967
  • Biology, Medicine
  • The Journal of biological chemistry
Abstract The capacity of the mitochondrial fraction from gastrocnemius muscle to oxidize pyruvate doubled in rats subjected to a strenuous program of treadmill running. Succinate dehydrogenase, reduced diphosphopyridine nucleotide dehydrogenase, DPNH cytochrome c reductase, succinate oxidase, and cytochrome oxidase activities, expressed per g of muscle, increased approximately 2-fold in hind limb muscles in response to the training. The concentration of cytochrome c was also increased 2-fold… Expand
Effect of exercise on α-glycerophosphate dehydrogenase activity in skeletal muscle☆
TLDR
Findings provide evidence that the adaptive response to prolonged exercise involves a change in the composition of the cristae of skeletal muscle mitochondria, rather than a simple uniform increase in size or number. Expand
Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training.
TLDR
Comparison of O2 consumption at the mitochondrial, muscle, and whole-animal levels revealed that maximal muscle oxidase activity was not an absolute limitation to VO2max, and it was concluded that other factors intervene to control the percentage of muscle O 2 consumption capacity which may be utilized during exercise. Expand
Response of mitochondrial enzymes to decreased muscular activity.
TLDR
The data support the hypothesis that a mitochondrial deficit is important in the progression of muscular atrophy and suggest that there were fewer mitochondria in atrophic than in control muscles. Expand
Effects of exercise on activity of heart and muscle mitochondria.
TLDR
The data show that exhaustion of trained rats causes a decrease in the capacity of skeletal muscle to oxidize important energy fuels, which is greater for heart mitochondria from untrained than trained animals. Expand
Adaptations in Mitochondrial Enzymatic Activity Occurs Independent of Genomic Dosage in Response to Aerobic Exercise Training and Deconditioning in Human Skeletal Muscle
TLDR
The findings demonstrate that the adaptations in mitochondrial enzymatic activity after aerobic endurance exercise training and the opposite effects of deconditioning are independent of changes in the number of mitochondrial genomes, and likely relate toChanges in the rate of transcription of mtDNA. Expand
Adaptation of mitochondrial ATP production in human skeletal muscle to endurance training and detraining.
TLDR
Both MAPR and mitochondrial enzyme activities are shown to increase with endurance training and to decrease with detraining. Expand
Enzymes involved in ketone utilization in different types of muscle: adaptation to exercise.
TLDR
Adaptive changes tend to make skeletal muscles more like heart muscle in their enzyme patterns and may help to explain why physically trained, as compared to untrained, individuals do not develop post-exercise ketosis. Expand
Significance of skeletal muscle oxidative enzyme enhancement with endurance training.
A theoretical model is proposed to explain how the increase in mitochondrial protein concentration, and therefore of the oxidative enzymes, that occurs with endurance training could operate to alterExpand
Effects of lactate administration on mitochondrial enzyme activity and monocarboxylate transporters in mouse skeletal muscle
TLDR
The results suggest that lactate can be a key factor for exercise‐induced mitochondrial adaptations, and that the efficacy of high‐intensity training is, at least partly, attributed to elevated blood lactate concentration. Expand
Effects of Denervation and Simple Disuse on Rates of Oxidation and on Activities of Four Mitochondrial Enzymes in Type I Muscle
TLDR
Results suggest nerve may regulate mitochondrial enzymes in type I muscle, and the mechanism appears to be different from that which regulates oxidative processes in type II muscle. Expand
...
1
2
3
4
5
...