Biochemical adaptation of human skeletal muscle to heavy resistance training and immobilization.

@article{MacDougall1977BiochemicalAO,
  title={Biochemical adaptation of human skeletal muscle to heavy resistance training and immobilization.},
  author={John D. MacDougall and Glenn Ward and Digby G. Sale and John R. Sutton},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1977},
  volume={43 4},
  pages={700-3}
}
Nine healthy subjects were studied under control conditions and following 5 mo of heavy resistance training and 5 wk of immobilization in elbow casts. Needle biopsies were taken from triceps brachii and analyzed for adenosine triphosphate (ATP), adenosine diphosphate (ADP), creatine (C), creatine phosphate (CP, and glycogen concentrations. Training resulted in an 11% increase in arm circumference and a 28% increase in maximal elbow extension strength. Immobilization resulted in decreases in arm… CONTINUE READING

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