Biochemical activity of reactive oxygen species scavengers do not predict retinal ganglion cell survival.

@article{Schlieve2006BiochemicalAO,
  title={Biochemical activity of reactive oxygen species scavengers do not predict retinal ganglion cell survival.},
  author={Christopher R Schlieve and Christopher J. Lieven and Leonard A Levin},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 9},
  pages={
          3878-86
        }
}
PURPOSE Retinal ganglion cells (RGCs) die as a result of axonal injury in a variety of optic neuropathies, including glaucoma. Reactive oxygen species (ROS) act as intracellular signaling molecules and initiate apoptosis in nerve growth factor-deprived sympathetic neurons and axotomized RGCs. Determination of the role of specific ROS relies on the use of small molecule or protein scavengers with various degrees of specificity. The pro- or anti-cell-death effect of several ROS generating and… CONTINUE READING

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