Biochemical Markers of In Vivo Hepatotoxicity

@article{Wm2016BiochemicalMO,
  title={Biochemical Markers of In Vivo Hepatotoxicity},
  author={Arika Wm and Nyamai Dw and Osano Ko and Ngugi Mp and Njagi Enm},
  journal={Journal of Clinical Toxicology},
  year={2016},
  volume={6},
  pages={1-8}
}
A chemical compound, whether of natural or of synthetic origin, brings about a toxicological effect when its dose is high enough or the duration of exposure is sufficient to cause an alteration in the normal homeostasis of body fluids and tissues. Therefore, the right dose differentiates a toxicant from a remedy. The body detoxifies drugs and other chemical compounds through key organs such as the liver. The liver plays a central role in the metabolism and excretion of xenobiotics which makes… 

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References

SHOWING 1-10 OF 80 REFERENCES
Mechanisms of hepatotoxicity.
TLDR
This review addresses recent advances in specific mechanisms of hepatotoxicity, including inducible nitric oxide synthase knockout mice, where nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead.
Liver Hypertrophy
TLDR
An international panel of experts convened to debate the evidence concluded that hepatomegaly as a consequence of hepatocellular hypertrophy without histologic or clinical pathology alterations indicative of liver toxicity was considered an adaptive and a non-adverse reaction.
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
TLDR
Proteomics can be applied for the identification and confirmation of peripheral biomarkers for altered liver function after toxicant exposure in drug-treated rats.
The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism*†
TLDR
A significant expression of UGT1A1 in human small intestine, an enzyme possessing considerable allelic variability and a polymorphic expression pattern in intestine are identified, which plays a major role not only in first pass metabolism, but also in the degree of interindividual variation in overall oral bioavailability.
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
TLDR
Characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome.
Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl.
TLDR
Data suggest in situ activation of CMT is necessary for the alveolar toxicity of this compound; however, activation does not occur in ATII cells, which suggests CYP450 activation was not involved in the in vitro phenomenon.
The enzymes, regulation, and genetics of bile acid synthesis.
  • D. Russell
  • Biology
    Annual review of biochemistry
  • 2003
TLDR
The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals and causes a spectrum of human disease; this ranges from liver failure in early childhood to progressive neuropathy in adults.
Biochemical diagnosis of liver disease
  • P. Wolf
  • Medicine
    Indian Journal of Clinical Biochemistry
  • 2008
TLDR
The focus of this paper is on the analytes which are associated with hepatic necrosis, cholestasis, defects in excretion and end stage hepatic disease which results in decreased synthetic function.
...
1
2
3
4
5
...