Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.

@article{Teufel2015BiochemicalEA,
  title={Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.},
  author={Robin Teufel and Frederick W Stull and Michael Meehan and Quentin Michaudel and Pieter C. Dorrestein and Bruce Allan Palfey and Bradley S Moore},
  journal={Journal of the American Chemical Society},
  year={2015},
  volume={137 25},
  pages={8078-85}
}
The ubiquitous flavin-dependent monooxygenases commonly catalyze oxygenation reactions by means of a transient C4a-peroxyflavin. A recent study, however, suggested an unprecedented flavin-oxygenating species, proposed as the flavin-N5-oxide (Fl(N5[O])), as key to an oxidative Favorskii-type rearrangement in the biosynthesis of the bacterial polyketide… CONTINUE READING