Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response

  title={Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response},
  author={Alessio Cardinale and Maria Chiara de Stefano and Cristiana Mollinari and Mauro Racaniello and Enrico Garaci and Daniela Merlo},
  journal={Neurochemical Research},
Sirtuin 6 (SIRT6) is a member of nicotinamide adenine dinucleotide-dependent deacetylase protein family and has been implicated in the control of glucose and lipid metabolism, cancer, genomic stability and DNA repair. Moreover, SIRT6 regulates the expression of a large number of genes involved in stress response and aging. The role of SIRT6 in brain function and neuronal survival is largely unknown. Here, we biochemically characterized SIRT6 in brain tissues and primary neuronal cultures and… CONTINUE READING


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