Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer

@article{Greenall2012BiochemicalCO,
  title={Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer},
  author={S. Greenall and J. Bentley and L. Pearce and J. Scoble and L. Sparrow and N. Bartone and Xiaowen Xiao and R. Baxter and L. Cosgrove and T. Adams},
  journal={The Journal of Biological Chemistry},
  year={2012},
  volume={288},
  pages={59 - 68}
}
Background: Aberrant processing of the pro-IGF-II transcript produces pro- and big-IGF-II, which are secreted in a range of cancers. Results: These induce potent receptor activation and cell proliferation and retard ternary complex formation with ALS and IGFBP-3 and -5. Conclusion: They elicit unique biological responses that can be completely different from IGF-II. Significance: Understanding the effects induced by these individual isoforms is crucial to elucidate their role in tumorigenesis… Expand
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