Biochemical Basis of Sestrin Physiological Activities.

@article{Ho2016BiochemicalBO,
  title={Biochemical Basis of Sestrin Physiological Activities.},
  author={Allison Ho and Chun-Seok Cho and Sim Namkoong and Uhn-Soo Cho and Jun Hee Lee},
  journal={Trends in biochemical sciences},
  year={2016},
  volume={41 7},
  pages={
          621-632
        }
}
Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough… CONTINUE READING
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