Biochemical, histomorphometric and densitometric changes in patients with multiple myeloma: effects of glucocorticoid therapy and disease activity.

@article{Diamond1997BiochemicalHA,
  title={Biochemical, histomorphometric and densitometric changes in patients with multiple myeloma: effects of glucocorticoid therapy and disease activity.},
  author={Terrence H. Diamond and Shiri Levy and Peter I. Day and Stephanie Barbagallo and Arumugam Manoharan and Yum K. Kwan},
  journal={British journal of haematology},
  year={1997},
  volume={97 3},
  pages={641-8}
}
It is unknown whether bone changes which can occur in multiple myeloma (MM) are due to cytokine-induced osteoclastic bone resorption from a clone of abnormal plasma cells or high-dose glucocorticoid therapy. We studied 25 MM patients treated for 1-12 years with combination chemotherapy, subdivided into two groups. Group 1 consisted of 12 patients with stage I and II myeloma and group 2 consisted of 13 patients with stage III MM. Their serum biochemistry, tetracycline-labelled bone… CONTINUE READING
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