Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase.

@article{Schallmey2013BiocatalyticAS,
  title={Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase.},
  author={Marcus Schallmey and Robert J. Floor and Bernhard Hauer and Michael Breuer and Peter A. Jekel and Hein J. Wijma and Bauke W Dijkstra and Dick B. Janssen},
  journal={Chembiochem : a European journal of chemical biology},
  year={2013},
  volume={14 7},
  pages={870-81}
}
Two highly engineered halohydrin dehalogenase variants were characterized in terms of their performance in dehalogenation and epoxide cyanolysis reactions. Both enzyme variants outperformed the wild-type enzyme in the cyanolysis of ethyl (S)-3,4-epoxybutyrate, a conversion yielding ethyl (R)-4-cyano-3-hydroxybutyrate, an important chiral building block for statin synthesis. One of the enzyme variants, HheC2360, displayed catalytic rates for this cyanolysis reaction enhanced up to tenfold… CONTINUE READING
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