Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase.

  title={Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase.},
  author={Marcus Schallmey and Robert J. Floor and Bernhard Hauer and Michael Breuer and Peter A. Jekel and Hein J. Wijma and Bauke W Dijkstra and Dick B. Janssen},
  journal={Chembiochem : a European journal of chemical biology},
  volume={14 7},
Two highly engineered halohydrin dehalogenase variants were characterized in terms of their performance in dehalogenation and epoxide cyanolysis reactions. Both enzyme variants outperformed the wild-type enzyme in the cyanolysis of ethyl (S)-3,4-epoxybutyrate, a conversion yielding ethyl (R)-4-cyano-3-hydroxybutyrate, an important chiral building block for statin synthesis. One of the enzyme variants, HheC2360, displayed catalytic rates for this cyanolysis reaction enhanced up to tenfold… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
10 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…