Biocatalysts by evolution.

@article{Jckel2010BiocatalystsBE,
  title={Biocatalysts by evolution.},
  author={Christian J{\"a}ckel and Donald Hilvert},
  journal={Current opinion in biotechnology},
  year={2010},
  volume={21 6},
  pages={753-9}
}
Proteins evolve by iterative cycles of mutation, selection and amplification. Analogous evolutionary strategies are being profitably exploited in the laboratory to generate and optimize biocatalysts for diverse biotechnological applications. In this review, we summarize recent efforts to improve this process by creating more effective protein libraries and more efficient screening/selection schemes. Targeted mutagenesis using simplified amino acid alphabets, statistical analyses of sequence… CONTINUE READING

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