Bioavailability studies with etodolac in dogs and man.

@article{Kraml1984BioavailabilitySW,
  title={Bioavailability studies with etodolac in dogs and man.},
  author={M. Kraml and L Cosyns and David R. Hicks and J Simon and John F. Mullane and Dushan Dvornik},
  journal={Biopharmaceutics \& drug disposition},
  year={1984},
  volume={5 1},
  pages={
          63-74
        }
}
The effects of formulation, particle size, coadministration of food, antacids, or antiulcer agents on the bioavailability of etodolac (ULTRADOL, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid), a novel non-steroidal anti-inflammatory agent, have been evaluated in dogs and man. The effects of dosage regimen and/or repetitive dosing on bioavailability were also determined. In man, capsule and tablet dosage forms containing micronized etodolac were shown to have a bioavailability… 
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It was concluded that, in rats and dogs, etodolac is well absorbed, is subject to extensive enterohepatic circulation, undergoes partial biotransformation, and is excreted primarily into the feces.
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TLDR
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