Bioavailability studies with etodolac in dogs and man.

  title={Bioavailability studies with etodolac in dogs and man.},
  author={M. Kraml and L Cosyns and David R. Hicks and J Simon and John F. Mullane and Dushan Dvornik},
  journal={Biopharmaceutics \& drug disposition},
  volume={5 1},
The effects of formulation, particle size, coadministration of food, antacids, or antiulcer agents on the bioavailability of etodolac (ULTRADOL, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid), a novel non-steroidal anti-inflammatory agent, have been evaluated in dogs and man. The effects of dosage regimen and/or repetitive dosing on bioavailability were also determined. In man, capsule and tablet dosage forms containing micronized etodolac were shown to have a bioavailability… 
Profile of etodolac: Pharmacokinetic evaluation in special populations
The pharmacokinetics of etodolac, a new nonsteroidal anti-inflammatory drug, were compared in normal subjects, in patients with renal and hepatic disease, and in elderly patients, suggesting that no alteration of etdolac dosage would be necessary in these high-risk groups.
Bioavailability and bioequivalence of two formulations of etodolac (tablets and suppositories).
The results indicate that the two routes of administration are bioequivalent and that the rectal route is an alternative administration route for etodolac.
Etodolac Clinical Pharmacokinetics
In elderly nonarthritic individuals with excellent kidney function, aging does not affect the pharmacokinetics of etodolac, and may be important because the acyl-glucuronides are renally cleared.
Pharmacokinetic modeling and simulation of etodolac following single oral administration in dogs
  • I. Baek
  • Medicine, Chemistry
    Xenobiotica; the fate of foreign compounds in biological systems
  • 2019
Etodolac is a nonsteroidal anti-inflammatory drug with selective cyclooxygenase-2 inhibition to treat pain and inflammation associated with osteoarthritis in humans and dogs and a two-compartment pharmacokinetic model with first-order absorption and elimination rate constants was successfully explained.
The Stereoselective Pharmacokinetics of Etodolac in Young and Elderly Subjects, and After Cholecystectomy
In all subjects, the plasma concentrations of R‐etodolac, which is pharmacologically inactive, greatly exceeded those of the pharmacologically active S‐enantiomer, and the results reflect the importance of considering stereoselectivity in evaluating the pharmacokinetics of etodolacs.
Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use.
From studies in small numbers of patients etodolac appears at least as effective as aspirin and better tolerated, and the relatively low incidence of gastrointestinal side effects in these studies awaits confirmation in well designed comparisons with widely used NSAIDs.
Effect of etodolac on the prostaglandin concentrations in the kidney of the normal rat
It is concluded that etodolac possesses only a very weak capacity to lower renal PGs, and therefore is unlikely to cause any renal complications related to PG biosynthesis inhibition.
Disposition and biotransformation of 14C-etodolac in man.
Microbial transformation of etodolac was employed to biosynthesize sufficient amounts of two urinary metabolites to facilitate structure elucidation and false positive tests for bilirubin in urine of patients treated with etdolac were found to be due to the two phenolic metabolites.
Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis.
Carprofen, etodolac, and meloxicam had greater efficacy than butorphanol in relief of acute pain in this acute pain model and serum CRP analysis was not useful to assess drug efficacy.


The metabolic disposition of etodolac in rats, dogs, and man.
It was concluded that, in rats and dogs, etodolac is well absorbed, is subject to extensive enterohepatic circulation, undergoes partial biotransformation, and is excreted primarily into the feces.
Piroxicam Pharmacokinetics in Man: Aspirin and Antacid Interaction Studies
The absorption and disposition of piroxicam are unaffected by the concomitant administration of aspirin and antiacids, and Salicylate plasma levels are similarly unaffected by piroXicam administration.
Anti-inflammatory and analgesic properties of etodolic acid in rats.
The potency of etodolic acid in the adjuvantArthritic rat suggests that this novel anti-inflammatory compound will be effective in the treatment of arthritic conditions of man.
Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids.
Results show that 1, 8-diethyl-1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acid (etodolic acid, USAN) is a potent agent, particularly active against a chronic rat model of inflammation and which has a relatively low acute ulcerogenic potential in the same species.
Chemistry and antiinflammatory activities of prodolic-acid and related 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-alkanoic acids. 1.
The synthesis and antiinflammatory activities of a series of 23 novel 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-alkanoic acids are described and some relationships between structure and activity are
Sensitive high-performance liquid chromatographic method for the determination of etodolac in serum.
A sensitive high-performance liquid chromatographic method for the determination of etodolac in serum was developed and showed the specificity of the method was demonstrated by the lack of response obtained with a variety of control sera, sera spiked with etdolac congeners, and sera obtained from rats treated with a range of other drugs.
Introduction to Statistical Analysis.
Welcome to SOCL 2201, a.k.a Astats@. Most likely, you enrolled in this course because Astats@ is required for your major. Why do LSU degree programs require stats? Probably because statistics are
Particle size of drugs and its relationship to absorption and activity.
  • J. Fincher
  • Chemistry
    Journal of pharmaceutical sciences
  • 1968