Bioavailability of oxytetracycline, tetracycline and chlortetracycline after oral administration to fed and fasted pigs.

@article{Nielsen1996BioavailabilityOO,
  title={Bioavailability of oxytetracycline, tetracycline and chlortetracycline after oral administration to fed and fasted pigs.},
  author={Poul Br{\"a}uner Nielsen and N. Gyrd-Hansen},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1996},
  volume={19 4},
  pages={305-11}
}
The disposition of oxytetracycline (OTC), tetracycline (TC) and chlortetracycline (CTC) was measured after intravenous and oral administration to pigs. Eighteen healthy pigs (six for each compound) weighing 22-43 kg received a dose of 10 mg/kg intravenously, and 45 mg/kg (OTC and TC) or 40 mg/kg (CTC) orally in both a fasted and a fed condition in a three-way crossover design. The three tetracyclines were present in plasma up to 30 hours after intravenous and after oral administration to fasted… CONTINUE READING

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