Bioavailability of modified‐release methylphenidate: influence of high‐fat breakfast when administered intact and when capsule content sprinkled on applesauce

@article{Lee2003BioavailabilityOM,
  title={Bioavailability of modified‐release methylphenidate: influence of high‐fat breakfast when administered intact and when capsule content sprinkled on applesauce},
  author={Lucy M-C Lee and Joanne Kepple and Yibin Wang and Stephen Freestone and Ray Bakhtiar and Yanfeng Wang and Mohammad Rumman Hossain},
  journal={Biopharmaceutics \& Drug Disposition},
  year={2003},
  volume={24}
}
Ritalin®, an immediate release form of racemic methylphenidate hydrochloride, has been available in the USA since 1955 and is used for the treatment of ADHD. The objective of this study was to evaluate the pharmacokinetics of modified‐release methylphenidate (highest single dose), Ritalin® LA, when administered under fasting condition, with a high‐fat breakfast, and when sprinkled on applesauce in healthy adult subjects. Blood samples were drawn for 24 h following a 40 mg oral administration… 

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