Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: Increasing the power of bioavailability tests

@article{Heck2005BioavailabilityOI,
  title={Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: Increasing the power of bioavailability tests},
  author={H A Heck and S. E. Jun. Buttrill and Norman W. Flynn and Robert L. Dyer and Michael Anbar and Thomas Cairns and Shrikant V. Dighe and Bernard E. Cabana},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={2005},
  volume={7},
  pages={233-248}
}
A new methodology for comparative bioavailability testing is described in which each drug formulation is compared with a stable isotope-labeled variant of the drug that is consumed orally in solution at the same time the tested formulation is ingested. The methodology is used to determine the comparative bioavailabilities of two commercially available brands of imipramine hydrochloride. The power of the new methodology to detect differences between drug formulations, when, in fact, such… Expand
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