Bioavailability of generic ritonavir and lopinavir/ritonavir tablet products in a dog model.

@article{Garren2010BioavailabilityOG,
  title={Bioavailability of generic ritonavir and lopinavir/ritonavir tablet products in a dog model.},
  author={Kevin W Garren and Sibtain Rahim and Kennan Marsh and John B. Morris},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 2},
  pages={626-31}
}
In this study, we explored the bioavailability in dogs and chemical potency of generic ritonavir and lopinavir/ritonavir tablet products manufactured by various pharmaceutical companies. Chemical potency of the products was examined by HPLC quantitation of ritonavir and lopinavir. Using a dog model, we determined point estimates for C(max) and AUC of ritonavir and lopinavir/ritonavir for eight generic products compared to Abbott's Norvir capsule and Kaletra tablet. Chemical potencies ranged… CONTINUE READING

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