Bioavailability of diclofenac potassium at low doses.

  title={Bioavailability of diclofenac potassium at low doses.},
  author={Burkhard Hinz and Julia Chevts and Bertold Renner and Henrike Wuttke and T. Rau and Andreas Schmidt and Istvan Szelenyi and Kay Brune and Ulrike Werner},
  journal={British journal of clinical pharmacology},
  volume={59 1},
AIM Diclofenac-K has been recently launched at low oral doses in different countries for over-the-counter use. However, given the considerable first-pass metabolism of diclofenac, the degree of absorption of diclofenac-K at low doses remained to be determined. The aim of this study was to determine the bioavailability of low-dose diclofenac-K. METHODS A randomized, three-way, cross-over study was performed in 10 subjects. Each received diclofenac-K, 22.5 mg via short-term i.v. infusion and… CONTINUE READING

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